Fungal keratitis (FK) is a severe, progressive, inflammatory ocular disease resulting from invasive growth of fungi into the cornea. Fungal keratitis is challenging to manage and can lead to blindness or loss of the affected eye. Nearly half of the causative organisms in FK are filamentous fungi, predominantly species of Aspergillus and Fusarium, of approximately equal frequency, followed in incidence by species of Candida, a dimorphic yeast. The purpose of this study was to better understand the pathogenesis and treatment of FK by associating antifungal susceptibility and multi-locus sequence-based fungal identification with clinical outcome of a naturally occurring model of FK in horses.
For more information, visit the published paper in PLOS https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214214
TEAM
Megan Cullen, North Carolina State University
Megan E. Jacob, North Carolina State University
Henry Van T. Cotter, North Carolina State University
Marc A. Cubeta, North Carolina State University
Ignazio Carbone, North Carolina State University
Brian C. Gilger, North Carolina State University